The U.S. Blood System: Under Pressure
Dr. Menitove discusses obstacles and pressure on U.S. blood centers and the U.S. blood supply.
Targeted Therapy to Trigger GVL: A Case for the Prosecution in FLT3-ITD–Mutant AML
Dr. Roberts sheds light on a mechanism by which a small molecule inhibitor targeting a leukemia-specific kinase mutation can trigger an effective CD8 T cell-mediated allo-i
Dr. Raje and Dr. Yee look at the RVD regimen (lenalidomide, bortezomib, and dexamethasone) as standard of care in newly diagnosed multiple myeloma.
Dr. Raje and Dr. Yee cover efforts to identify new pathways to treat multiple myeloma relapse.
Dr. Raje and Dr. Yee covers the DETERMINATION trial, which will provide greater clarity on how long to use maintenance lenalidomide and whether longer maintenance will narrow the gap in PFS between upfront and deferred transplant approaches.
Drs. Raje, Yee, and Lohr discuss the development of a new tool for exploring the complexity of multiple myeloma through circulating myeloma cells, which could replace bone marrow biopsies and permits analysis to be performed at multiple time points.
Dr. Raje, Dr. Yee and Dr. O'Donnell discuss various daratumumab combinations that have emerged as options for the treatment of multiple myeloma.
Dr. Raje and Dr. Yee discuss a study that looks at the use of pembrolizumab in combination with lenalidomide or pomalidomide to treat multiple myeloma as a form of checkpoint inhibition, a new important tool in cancer treatment.
Drs. Raje, O'Donnell, and Yee discuss progress in drugs for the treatment of multiple myeloma, especially immuno-oncology and monoclonal antibodies (MoABs).
Drs. Raje and Yee discuss two trials with elotuzumab and daratumumab that use monoclonal antibodies in the treatment of multiple myeloma.
Dr. Raje and Dr. Yee discuss the need for new agents in the therapy or treatment of patients with multiple myeloma, taking into account the FDA approval of penobinostat, and a study that looks at HDAC inhibition.
Dr. Yee and Dr. Raje review several trials to explain new courses of treatment for multiple myeloma, specifically an oral, active, well-tolerated PI.
May-June 2018Volume 15, Issue 3
A new Compendium providing updated clinical information to "Ask the Hematologist" articles published in The Hematologist from 2010 to 2015 is now available.
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by American Society of Hematology