Are Transfusions a Barrier to High-Quality End-of-Life Care in Hematology?
Dr. LeBlanc and Dr. Litzow take a look at an issue within the field consisting of hematologists referring their patients to hospice late or not at all even when there are s
Remission: More Than Meets the Eye
Dr. Teachey reviews a study that suggests that patients in morphologic remission but with high minimal residual disease have inferior outcomes.
Dr. Becker studies clonal hematopoiesis and how somatic cells may contribute to clonal expansion and development of myeloid neoplasms with the acquisition of additional cooperating mutations.
Dr. Becker discusses the many mutations identified in acute myeloid leukemia and the efforts of investigators to find a practical application of this information in modifying treatment.
Dr. Becker discusses an event called chromothripsis, which entails a catastrophic change of genome structure and acquisition of multiple mutations through chromosomal rearrangements, as a cause for cancer.
Dr. Becker takes a close look at implanted devices for chemotherapy testing of tumors, technological limitations, and major challenges for future development of the technology.
Dr. Becker compares ibrutinib-based therapy and FCR chemoimmunotherapy for untreated younger patients with chronic lymphocytic leukemia (CLL).
Dr. Becker discusses the origins of therapy-related myelodysplastic syndrome and/or acute myeloid leukemia.
Based largely on vector innovation, gene therapy for hematologic disorders has advanced tremendously in the past decade, with 2014 witnessing sustained improvement in selected inherited diseases.
Drs. Huang and Becker review a study suggesting that replication stress contributes to the chromosomal damage and functional decline characteristic of old HSCs.
Dr. Becker reviews a study on incorporating gene editing into certain gene therapy strategies.
Dr. Becker reviews a study that has identified a mechanism by which the microenvironment confers resistance to antibody therapy.
July-August 2018Volume 15, Issue 4
A new Compendium providing updated clinical information to "Ask the Hematologist" articles published in The Hematologist from 2010 to 2015 is now available.
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by American Society of Hematology