The Cure Sickle Cell Initiative: Catalyzing Progress via Innovative Interfaces Between NIH, Patients, Academics, ASH, and the Private Sector
Dr. Edward Benz provides some background on the discovery of sickle cell disease and development of the Cure Sickle Cell Initiative. Dr. Ify Osunkwo adds further perspectiv
A New Standard of Care for Children and Young Adults With T-cell Acute Lymphoblastic Leukemia
Dr. Teachey reviews a study that shows outstanding outcomes for children and young adults with T-cell acute lymphoblastic leukemia that have raised the bar and established
Dr. Koury reviews several publications that have advanced our understanding of steady-state and emergency production rates for platelets, neutrophils, and erythrocythes.
Dr. Koury studies increase in platelet production and size due to the IL-1α-induced megakaryocyte rupture mechanism of rapid platelet production.
Dr. Koury looks at a study that demonstrates that C3b-mediated erythrocyte clearance of damaged plasma proteins can improve treatment of diseases characterized by tissue accumulation of misfolded or denatured proteins.
Dr. Koury discusses how inhibiting autophagy can increase production of functional neutrophils in the treatment of patients with chemotherapy-induced neutropenia.
Dr. Koury evaluates the stalled blood flow in increased percentages of cerebral capillaries in PV and ET.
Dr. Koury evaluates the safety and efficacy of Roxadustat in the treatment of anemia in dialysis patients.
Among the most important discoveries for hematologists in 2014 is the report of Dr. Leon Kautz and colleagues, from the laboratory of Dr. Tomas Ganz, that identified erythroferrone (ERFE) as a hormone produced by erythroblasts that suppresses hepcidin transcription in the liver.
Dr. Koury looks at the role of heme-regulated differentiation on monocytes and macrophages in hemolsysis, iron metabolism, and macrophage differentiation.
Dr. Koury examines the implications of the identification of ERFE as an erythropoietic regulator of iron mobilization and absorption through hepcidin suppression.
Dr. Koury reviews a study that demonstrates the crucial role that Foxc1 expression in bone marrow plays in the establishment and maintenance
of the hematopoietic niche.
November-December 2018Volume 15, Issue 6
A new Compendium providing updated clinical information to "Ask the Hematologist" articles published in The Hematologist from 2010 to 2015 is now available.
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