Are Transfusions a Barrier to High-Quality End-of-Life Care in Hematology?
Dr. LeBlanc and Dr. Litzow take a look at an issue within the field consisting of hematologists referring their patients to hospice late or not at all even when there are s
Remission: More Than Meets the Eye
Dr. Teachey reviews a study that suggests that patients in morphologic remission but with high minimal residual disease have inferior outcomes.
Dr. Quinn looks at progress made in the field of sickle cell disease (SCD) including an array of potential new therapies.
Dr. Quinn discusses the REACH study as part of several studies that look at hydroxyurea for the treatment of children with sickle cell anemia in sub-Saharan Africa.
Dr. Quinn talks about safety concerns regarding targeted fetal hemoglobin induction therapy and the role of BCL11A in human neurodevelopment.
Dr. Quinn studies experiments that evaluate DGKE deficiency and its effect in activation and damage of endothelial cells, and as a cause of eHUS independent of complement activation.
In an attempt to explain racial disparity in the risk of chronic kidney disease, Dr. Quinn discusses the adverse effects of sickle cell trait in the kidneys and an association between sickle cell trait and the occurrence of CKD in African Americans.
Among the most important clinical advances for hematologists in 2014,
especially those who care for patients with sickle cell disease, is the report by Dr.
Michael DeBaun and colleagues of the results of the Silent Cerebral Infarct Transfusion Trial (SIT Trial).
Dr. Quinn looks into the effectiveness of anti-adhesive therapy for sickle cell disease.
Dr. Quinn explores a study on causes of alloimmunization in chronically transfused individuals with SCD.
Dr. Quinn reviews a study that may add to the growing list of mechanisms of action for the multiple therapeutic benefits
of HU beyond induction of HbF expression.
Dr. Charles Quinn reviews a study that discovered an association between high von Willebrand factor antigen levels (in 8/20 patients) and improved thromboelastographic measurements that might account for a decreased
tendency toward bleeding.
July-August 2018Volume 15, Issue 4
A new Compendium providing updated clinical information to "Ask the Hematologist" articles published in The Hematologist from 2010 to 2015 is now available.
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by American Society of Hematology