The U.S. Blood System: Under Pressure
Dr. Menitove discusses obstacles and pressure on U.S. blood centers and the U.S. blood supply.
Targeted Therapy to Trigger GVL: A Case for the Prosecution in FLT3-ITD–Mutant AML
Dr. Roberts sheds light on a mechanism by which a small molecule inhibitor targeting a leukemia-specific kinase mutation can trigger an effective CD8 T cell-mediated allo-i
Dr. Parker wraps up his three-year term as Editor-in-Chief of The Hematologist and welcomes Jason Gotlib, MD, as he assumes the Editor-in-Chief role (2015 to 2017).
Dr. Charles Parker discusses personalized medicine and the importance of developing regulatory and oversight policies and protecting patients' rights.
To most, the complement system resides in one of the dark corners of hematology, occasionally dimly illuminated when the direct antibody test is reported as "positive" for C3 in a patient with autoimmune hemolytic anemia. Undeniably, the complement system, with its three overlapping pathways (classical, alternative, and lectin), is complex, but the development of new and emerging targeted therapies for complement-mediated diseases necessitates understanding of this arcane system.
Martha Glenn, MD, and Charles Parker, MD2010 11 01Study Title SWOG 0801 - A Phase II Study of Iodine 131 Labeled Tositumomab in Combination With Cyclophosphamide, Doxorubicin, Vincristine, Prednisone, and Rituximab (RCHOP) Therapy for Patients With Advanced Stage Follicular Non
Charles Parker, MD2010 11 01Dr. Parker indicated no relevant conflicts of interest. Cavazzana Calvo M, Payen E, Negre O, et al. Transfusion independence and HMGA2 activation after gene therapy of human β thalassaemia. Nature. 2010 467 318 322. There
An update on the following clinical trial: Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea Therapy in the Treatment of High-Risk Polycythemia Vera and High-Risk Essential Thrombocythemia
In the not-so-distant future, clinicians may order whole-genome sequencing of patient DNA the way we now order an MRI. In the run-up to the routine clinical use of whole-genome sequencing, investigators are taking advantage of this remarkable technical achievement to characterize the human genome and to solve challenging genetic and pathophysiological problems.
Haploidentical transplantation could just as easily be called haplounidentical transplantation, because recipient and donor are matched at HLA loci on one chromosome 6 (haploidentical) but not on the other (haplounidentical).
In this paper, Yarde and colleagues from H. Lee Moffitt Cancer Center provide for the first time evidence that NF-κB subunits RelB/p50 transcriptionally activate the Fanconi anemia/BRCA (FA/BRCA) pathway in myeloma.
The critical importance of CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) in immune homeostasis and protection against autoimmunity is illustrated by the consequences of inherited mutation of the X-linked gene Foxp3, a member of the forkhead/winged helix family of transcription factors.
May-June 2018Volume 15, Issue 3
A new Compendium providing updated clinical information to "Ask the Hematologist" articles published in The Hematologist from 2010 to 2015 is now available.
AMERICAN SOCIETY OF HEMATOLOGY
2021 L Street NW, Suite 900, Washington, DC 20036
Phone 202-776-0544 | Fax 202-776-0545
by American Society of Hematology