American Society of Hematology

About the ASH Agenda

The field of hematology has experienced a recent surge in progress thanks to novel technologies, mechanistic insights, and cutting-edge therapeutic strategies that have driven significant and meaningful advances in the quality of care. These foundational insights are reframing modern research with the continued goal of improving outcomes and discovering cures for the most challenging hematologic diseases.

Whereas certain blood disorders have benefited from the tremendous progress in clinical research and development of new therapies, other areas have continuing challenges such as disease heterogeneity and the complex combinations of genetic drivers that have evaded effective treatment to date. A wide variety of blood-related diseases – from malignancies such as lymphoma and leukemia, to non-malignant diseases including hemoglobinopathies, blood platelet, and coagulation disorders, including orphan diseases of the hematopoietic system – continue to be associated with significant morbidity and mortality and demand attention to reduce their burden and improve the quality of care worldwide.

Today, the research community looks to emerging technologies and tools in the areas of genetics and epigenetics, gene therapies, and regenerative medicine to identify areas that have strong potential to make a dramatic impact on patient care across a range of diseases.

This Agenda serves as a roadmap for the prioritization of research support across the hematology community, including recommendations for dedicated resources from funding agencies and foundations that will equip researchers today and in the future to make truly practice-changing discoveries. These specific and critically important research questions must be answered to gain the insights that will launch the field into the next generation of care for hematologic conditions.

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