Beginning with this issue, a new column called “Editors’ Choice” will appear in The Hematologist on a regular basis. This concept was developed in conjunction with the new editorial team of Blood. Dr. Bob Löwenberg (Editor-in-Chief) and Dr. Nancy Berliner (Deputy Editor-in-Chief) will combine efforts to identify some of the most outstanding Blood articles that have appeared either in print or online during the two-month interval between issues of The Hematologist. The citations will be annotated to provide readers both with a concise description of the thrust of the article and an explanation of why the paper is particularly important. The goal is to underscore the remarkable research that is published in Blood and to highlight the exciting progress that is being made in the field. We hope you will enjoy the column, and we look forward to receiving your comments about this new initiative.
MARCH 7, 2013
Matsushima H, Geng S, Lu R, et al. Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells. Blood. 2013;121:1677-1689.
Geng S, Matsushima H, Okamoto T, et al. Emergence, origin, and function of neutrophil-dendritic cell hybrids in experimentally induced inflammatory lesions in mice. Blood. 2013;121:1690-1700.
These two manuscripts report the first in vivo identification of a newly discovered neutrophil-dendritic cell hybrid. This work extends previously published studies on the functional plasticity of neutrophils and reports on the adaptive immune capabilities of this major granulocyte subset. Both manuscripts describe the function of this novel population of hybrid neutrophildendritic cells that appear to have an important role in inflammation.
FEBRUARY 28, 2013
McIntyre BAS, Ramos-Mejia V, Rampalli S, et al. Gli3-mediated hedgehog inhibition in human pluripotent stem cells initiates and augments developmental programming of adult hematopoiesis. Blood. 2013;121:1543-1552.
Controlled modulation of the hematopoietic differentiation process of pluripotent stem cells holds great promise for therapeutic application for a range of blood diseases. This manuscript reports results of experiments using chemical activators, inhibitors, and suppressed or over-expressed regulators to manipulate a critical pluripotent stem cell differentiation pathway known as the hedgehog. Experimental data show that augmentation of the hedgehog intracellular pathway alters the output from human pluripotent stem cells to produce hematopoietic cells that have acquired some aspects of adult hematopoiesis. These findings represent a major advance in the fields of developmental biology and regenerative medicine.
FEBRUARY 21, 2013
Amabile G, Welner RS, Nombela-Arrieta C, et al. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2013;121:1255-1264.
Induced pluripotent stem (iPS) cells offer the promise of individualized cellular therapy; however, to date, the derivation of hematopoietic stem cells (HSCs) from iPS cells has proved inefficient. In this manuscript, Amabile and colleagues report successful derivation of HSCs from human iPS cells. The authors report that immunodeficient mice injected with iPS cells form teratomas from which transplantable myeloid and lymphoid cells can be derived. These observations represent substantial progress toward the ultimate goal of using iPS cells as a means of individualizing treatment of blood disorders.
FEBRUARY 14, 2013
Rivat C, Booth C, Alonso-Ferrero M, et al. SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease. Blood. 2013;121:1703-7076.
This manuscript provides proof of principle that several key features of X-linked lymphoproliferative disease (XLP1) can be corrected by gene therapy. The observation, that immune functions that are defective in this disorder can be normalized, represents a major step toward the development of clinically applicable gene therapy for infants with this severe inborn immune disorder.
JANUARY 31, 2013
Bugl S, Wirths S, Radsak MP, et al. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood. 2013;121:723-733.
Determining how normal neutrophil numbers are maintained is a particularly important and intriguing issue in hematology. In this manuscript, the authors address this historically challenging problem by developing a model to study the mechanisms regulating neutropoiesis at steady state (i.e., in the absence of infection). The investigators identify a process of steady-state neutrophil homeostasis that involves a novel, direct link between granulopoiesis and the toll-like receptor (TLR)-triggered pathway.
JANUARY 24, 2013
Sepulveda FE, Debeurme F, Ménasché G, et al. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. Blood. 2013;121:595-603.
Kögl T, Müller J, Jessen B, et al. Hemophagocytic lymphohistiocytosis (HLH) in Syntaxin-11 deficient mice: T-cell exhaustion limits fatal disease. Blood. 2013;121:604-613.
Two papers published together in the January 24 issue of Blood elucidate the heterogeneity of familial hemophagocytic lymphohistiocytosis (fHLH), a rare, often fatal immunologic disorder caused by impaired cell-mediated cytotoxicity that has been linked to mutations in several related genes. In these back-to-back papers, researchers elucidate the range of immune and clinical abnormalities that characterize the different genetic subtypes of fHLH.
Additional Blood Articles and Features
We would also like to alert readers that the second Blood
Spotlight article (“Carfilzomib” authored by Dr. K. Martin Kortuem and
Dr. A. Keith Stewart) appeared in the February 7 issue. Blood Spotlights
are brief articles that focus on emerging scientific and clinical
developments or on a recent burst of advances within a circumscribed
area. Also of note, the first of four review series in 2013 appeared in
the April 18 issue. That review, with Dr. Margaret Goodell as guest
editor, focused on epigenetics in hematology. Readers should also be
aware that the second Blood Hub, a centralized place for readers to find
content, launched in April; it focuses on thrombocytopenia.