Below you will find a collection of articles from Hematology, the ASH Education Program, written by experts in the field about current treatments for marrow failure syndromes, including myelodysplastic syndromes (MDS). This Web site also provides links to organizations that inform and support MDS patients and their families.

Acquired

Aplastic Anemia

• Classification of Childhood Aplastic Anemia and Myelodysplastic Syndrome (2011)  
• Clonal Evolution in Aplastic Anemia (2011) 
• Diagnosis and Management of Aplastic Anemia (2011) 
• Therapy for Aplastic Anemia (2011) 
• Pathophysiologic Mechanisms in Acquired Aplastic Anemia (2006) 

Myelodysplastic Syndromes

• The Changing Classification of Myelodysplastic Syndromes: What’s In A Name? (2009) 
• Treatment of MDS: Something Old, Something New, Something Borrowed... (2009) 
• Supportive Care and Chelation Therapy In MDS: Are We Saving Lives Or Just Lowering Iron? (2009) 
• Myelodysplastic Syndromes: An Historical Perspective (2008) 
• MDS: A Stem Cell Disorder - But What Exactly Is Wrong with the Primitive Hematopoietic Cells in This Disease? (2008) 
• The Role of JAK2 Mutations in RARS and Other MDS (2008) 
• Epigenetic Modulation and Other Options to Improve Outcome of Stem Cell Transplanation in MDS (2008) 

Paroxysmal Nocturnal Hemoglobinuria 

• Management of Paroxysmal Nocturnal Hemoglobinuria in the Era of Complement Inhibitory Therapy (2011) 
• Paroxysmal Nocturnal Hemoglobinuria: An Historical Overview (2008) 
• Which Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Should Be Treated with Eculizumab? (2008) 
• The Pathophysiology of Disease in Patients with Paroxysmal Nocturnal Hemoglobinuria (2008) 
• Paroxysmal Nocturnal Hemoglobinuria: Stem Cells and Clonality (2008) 
• The Role of Complement Inhibition in PNH (2008) 

General

• Clinical Approach to Marrow Failure (2009) 
• Telomeres and Marrow Failure (2009) 
• Bone Marrow Failure as a Risk Factor for Clonal Evolution: Prospects for Leukemia Prevention (2007) 

Inherited

• Congenital Sideroblastic Anemias: Iron and Heme Lost in Mitochondrial Translation (2011) 
• Diamond Blackfan Anemia (2011) 
• Dyskeratosis Congenita (2011) 
• Fanconi Anemia (2011) 
• Telomeres and Marrow Failure (2009) 
• Congenital Neutropenia (2009) 
• Diagnosis, Genetics, and Management of Inherited Bone Marrow Failure Syndromes (2007) 

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