American Society of Hematology

Bleeding Disorders

Bleeding disorders are a group of conditions that result when the blood cannot clot properly. In normal clotting, platelets stick together and form a plug at the site of an injured blood vessel. Proteins in the blood called clotting factors then interact to form a fibrin clot, which holds the platelets in place and allows healing to occur at the site of the injury while preventing blood from escaping the blood vessel. While too much clotting can lead to heart attack and stroke, the inability to form clots can be very dangerous as well, as it can result in excessive bleeding.

Hemophilia is perhaps the most well-known bleeding disorder, although it is relatively rare. It affects mostly males. Many more people are affected by von Willebrand disease, the most common bleeding disorder in America. Von Willebrand disease can affect both males and females. You can find information on other bleeding disorders by following the links at the bottom of this page.

Am I at Risk?

Bleeding disorders such as hemophilia and von Willebrand disease result when the blood lacks certain clotting factors. These diseases are almost always inherited, although in rare cases they can develop later in life if the body forms antibodies that fight against the blood's natural clotting factors. Individuals and pregnant women with a family history of bleeding disorders should talk to their doctors about detection and treatment. Symptoms of bleeding disorders may include:

  • Easy bruising
  • Bleeding gums
  • Heavy bleeding from small cuts or dental work
  • Unexplained nosebleeds
  • Heavy menstrual bleeding
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What Is Hemophilia and How Is It Treated?

Hemophilia is a rare, typically inherited, bleeding disorder that can range from mild to severe, depending on how much clotting factor is present in the blood. Hemophilia is classified as Type A or Type B, based on which type of clotting factor is lacking (factor VIII in Type A and factor IX in Type B). Hemophilia results from a genetic defect found on the X chromosome.  Women, who have two X chromosomes, can pass the disease onto their sons but will be not be affected by the disease unless both X chromosomes have the defective gene; this is very rare. On the other hand, males, who have one X and one Y chromosome, will be affected by hemophilia if their one X chromosome has the defective gene.

Because blood does not clot properly without enough clotting factor, any cut or injury carries the risk of excessive bleeding. In addition, people with hemophilia may suffer from internal bleeding that can damage joints, organs, and tissues over time.

In the past, people with hemophilia were treated with transfusions of factor VIII obtained from donor blood, but by the early 1980s these products were discovered to be transmitting blood-borne viruses, including hepatitis and HIV. Thanks to improved screening techniques, and a major breakthrough that enabled scientists to create synthetic blood factors in the laboratory by cloning the genes responsible for specific clotting factors, today's factor-replacement therapies are pure and much safer than ever before.

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What Is von Willebrand Disease and How Is It Treated?

Von Willebrand disease is an inherited condition that results when the blood lacks von Willebrand factor, a protein that helps the blood to clot and also carries another clotting protein, factor VIII. It is usually milder than hemophilia and can affect both males and females. Von Willebrand disease is classified into three different types (Types 1, 2, and 3), based on the levels of von Willebrand factor and factor VIII activity in the blood. Type 1 is the mildest and most common form; Type 3 is the most severe and least common form.

With early diagnosis, people with von Willebrand disease can lead normal, active lives. People with mild cases may not require treatment, but should avoid taking drugs that could aggravate bleeding, such as aspirin and ibuprofen, without first consulting with a doctor. More serious cases may be treated with drugs that increase the level of von Willebrand factor in the blood or with infusions of blood factor concentrates. It is important for people with von Willebrand disease to consult with their doctors before having surgery, having dental work, or giving birth, so that proper precautions can be taken to prevent excessive bleeding. You may be referred to a hematologist, a doctor who specializes in the treatment of blood disorders.

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Where Can I Find More Information?

If you find that you are interested in learning more about blood diseases and disorders, here are a few other resources that may be of some help:

Results of Clinical Studies Published in Blood

Search Blood, the official journal of ASH, for the results of the latest blood research. While recent articles generally require a subscriber login, patients interested in viewing an access-controlled article in Blood may obtain a copy by e-mailing a request to the Blood Publishing Office.

Patient Groups

A list of Web links to patient groups and other organizations that provide information.

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