Harold Varmus Sworn in as Director of National Cancer Institute – Prioritizes Reform of the Clinical Trials System and Calls for Narrower, More Realistic Focus in Research

Former National Institutes of Health (NIH) director and Nobel laureate Harold Varmus, MD, was sworn in as the new director of the National Cancer Institute (NCI). Health and Human Services Secretary Kathleen Sebelius praised Dr. Varmus at the ceremony, stating that his leadership represents "the opening of a new chapter for NCI."

Later that day, Dr. Varmus held a town hall meeting with NCI staff and the research community to give a preview of his objectives for his tenure as NCI director. During this meeting, he stressed that "everything we do and everything that we say will be based on evidence," and that NCI needed to "pay attention to the repair of some things that are obviously dysfunctional in the system." Dr. Varmus cited reform of the clinical trials system and a readjustment of the cancer drug approval and regulation process as top priorities.

He also suggested that it was important for the scientists and administrators at NCI to reframe the questions they are trying to answer in order to provide clearer goals for researchers. NCI should help researchers focus "with a new specificity, based on new developments in our science, and look at questions that are not pie in the sky, but have a substantial prospect of answerability in the foreseeable future." To that end, Dr. Varmus intends to stage a series of meetings across the country with experts in a variety of fields in order to "try to establish a list of provocative, answerable questions that will help our scientists think about what the next steps ought to be."

Dr. Varmus was a co-recipient of the Nobel Prize in Physiology or Medicine in 1989 for his ground-breaking work studying the genetic basis for cancer. After serving as NIH Director from 1993 through 1999, he spent 10 years as president of Memorial Sloan-Kettering Cancer Center in New York City.

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