The 2011 Scientific Committee Sessions will be held Saturday, December 10, and Sunday, December 11. Each session will be offered twice. Invited abstracts of these sessions will be published in the Program Book and the abstract issue of Blood (the Abstract Book). 

• Ad Hoc Scientific Committee on Bone Marrow Failure
• Ad Hoc Scientific Committee on Plasma Cell Neoplasia
• Scientific Committee on Blood Disorders in Childhood
• Scientific Committee on Hematopathology and Clinical Laboratory Hematology
• Scientific Committee on Hematopoiesis
• Scientific Committee on Hemostasis
• Scientific Committee on Immunology and Host Defense
• Scientific Committee on Iron and Heme
• Scientific Committee on Lymphoid Neoplasia
• Scientific Committee on Myeloid Biology
• Scientific Committee on Myeloid Neoplasia
• Scientific Committee on Platelets
• Scientific Committee on Red Cell Biology
• Scientific Committee on Stem Cells and Regenerative Medicine
• Scientific Committee on Thrombosis and Vascular Biology
• Scientific Committee on Transfusion Medicine
• Scientific Committee on Transplantation Biology

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Ad Hoc Scientific Committee on Bone Marrow Failure

p53, Ribosome, and Diamond-Blackfan Anemia

Chair(s):

Monica  Bessler, MD, PhD
University of Pennsylvania School of Medicine
Philadelphia,  PA,  USA

Speaker(s):

Harvey  F.  Lodish, PhD
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology 
Cambridge,  MA,  USA
From Hematopoietic Stem Cell to Erythroblast: Regulation of Red Cell Production At Multiple Levels

Stefan  Karlsson, MD, PhD
Lund University 
Lund,  Sweden
Diamond-Blackfan Anemia: Erythropoiesis Lost in Ribosome Biosynthesis

Guillermina  (Gigi)  Lozano, PhD
University of Texas MD Anderson Cancer Center 
Houston,  TX,  USA
p53-Mediated Stress and Tissue-Dependent Cell Fate Decisions; Implications for p53 Targeting

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Ad Hoc Scientific Committee on Plasma Cell Neoplasia

Inflammation, Autoimmunity, and Plasma Cells

Chair(s):

Nikhil  C.  Munshi, MD
Dana-Farber Cancer Institute, Harvard Medical School
Boston,  MA,  USA

Speaker(s):

Glenn  Dranoff, MD
Dana-Farber Cancer Institute, Harvard Medical School 
Boston,  MA,  USA
The Interplay of Inflammation and Cancer

Chen  Dong, PhD
The University of Texas MD Anderson Cancer Center 
Houston,  TX,  USA
Th17 Cells and Associated Cytokines in Inflammation and Cancer

Warren  J.  Leonard, MD
National Institutes of Health 
Bethesda,  MD,  USA
The Yin and Yang of Interleukin-21 in Allergy, Autoimmunity and Cancer

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Scientific Committee on Blood Disorders in Childhood

Good Cells Gone Bad: Hematologic Malignancy Predisposition Syndromes

Chair(s):

Lillian  Sung, MD, PhD
The Hospital for Sick Children
Toronto,  ON,  Canada

Catherine  M.  Bollard, MD
Baylor College of Medicine, Texas Children's Hospital, The Methodist Hospital
Houston,  TX,  USA

Speaker(s):

Richard  A.  Gatti, MD
University of California Los Angeles 
Los Angeles,  CA,  USA
Ataxia Telangiectasia

Shai  Izraeli, 
Faculty of Medicine, Tel Aviv University 
Tel Aviv,  Israel
Acute Lymphocytic Leukemia and Down Syndrome

Cliona  M.  Rooney, PhD
Baylor College of Medicine 
Houston,  TX,  USA
EBV-Induced Lymphoproliferation

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Scientific Committee on Hematopathology and Clinical Laboratory Hematology

Microparticles in Hematologic Disorders

Chair(s):

Cecile  Kaplan-Gouet, MD, PhD
Institut National de la Transfusion Sanguine
Paris,  France

Speaker(s):

Nigel  Mackman, PhD
University of North Carolina at Chapel Hill 
Chapel Hill,  NC,  USA
Role of Microparticles in Hemostasis and Thrombosis

Jeffrey  Zwicker, MD
Beth Israel Deaconess Medical Center, Harvard Medical School 
Boston,  MA,  USA
State-of-the-Art and Current Controversies in the Detection and Quantitation of Tissue Factor-Bearing Microparticles

Roy  L.  Silverstein, MD
Medical College of Wisconsin 
Milwaukee,  WI,  USA
Activation of Vascular Cells by Microparticles and Other Danger Signals Via the CD36 Scavenger Receptor

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Scientific Committee on Hematopoiesis

Role of Notch Signaling in Normal and Malignant Hematopoiesis

Chair(s):

Alan  B.  Cantor, MD, PhD
Children's Hospital Boston and Dana-Farber Cancer Institute, Harvard Medical School
Boston,  MA,  USA

Speaker(s):

Iannis  Aifantis, PhD
New York University School of Medicine 
New York,  NY,  USA
The Notch Signaling Pathway as a Suppressor of Myeloid Transformation

Ivan  Maillard, MD, PhD
University of Michigan 
Ann Arbor,  MI,  USA
Notch Signaling in Graft-Versus-Host Disease

Anna  Bigas, PhD
Institut Municipal d’Investigació Mèdica - Hospital del Mar Research Institute 
Barcelona,  Spain
Role of Notch Signaling in Hematopoietic Stem Cell Function

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Scientific Committee on Hemostasis

Hemostatic Factors in Cancer Biology

Chair(s):

Anna  Falanga, MD
Ospedali Riuniti di Bergamo
Bergamo,  Italy

Speaker(s):

Janusz  W.  Rak, MD, PhD
Montreal Childrens Hospital 
Montreal,  QC,  Canada
Oncogenic Regulation of Tissue Factor Expression

Jay  L.  Degen, PhD
Cincinnati Children's Research Foundation 
Cincinnati,  OH,  USA
Thrombin Control Mechanisms and Thrombin Targets in Cancer Biology

C. Arnold  Spek, PhD
Amsterdam Medical Center 
Amsterdam,  Netherlands
The Role of Activated Protein C in Cancer

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Scientific Committee on Immunology and Host Defense

Inborn Errors of Immunity: Recent Advances

Chair(s):

Pavan  Reddy, MD
University of Michigan
Ann Arbor,  MI,  USA

Speaker(s):

David  Rawlings, MD
Pediatrics and Immunology, University of Washington School of Medicine 
Seattle,  WA,  USA
Clinical Insights Derived From B-Cell Immunodeficiency Disorders

Steven  M.  Holland, MD
National Institute of Allergy and Infectious Diseases, National Institutes of Health 
Bethesda,  MD,  USA
Novel Defects in Host Defense Evinced As Nontuberculous Mycobacterial and Dimorphic Mold Infections: GATA2 Deficiency, STAT1 Mutations, Anticytokine Autoantibodies

Alain  Fischer, MD, PhD
Institut National de la Santé et de la Recherche Médicale 
Paris,  France
Primary T Cell Immunodeficiencies and Autoimmunity

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Scientific Committee on Iron and Heme

Iron and Heme Sensing in Red Cells and Anemia

Chair(s):

Carole  Beaumont, PhD
Institut National de la Santé et de la Recherche Médicale
Paris,  France

Speaker(s):

Matthias  W.  Hentze, MD
The European Molecular Biology Laboratory 
Heidelberg,  Germany
Iron Regulatory Proteins in Systemic Iron Metabolism and Erythropoiesis

Jane-Jane  Chen, PhD
Harvard-MIT Division of Health Sciences and Technology 
Cambridge,  MA,  USA
Heme-Regulated eIF2α Kinase in Erythropoiesis and Oxidative Stress

Janis  L.  Abkowitz, MD
University of Washington 
Seattle,  WA,  USA
Why Do Erythroid Cells Need to Export Heme?

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Scientific Committee on Lymphoid Neoplasia

(Dys-) Regulation of Cell Metabolism in Lymphoid Neoplasia

Chair(s):

Gertjan  J.  Kaspers, MD, PhD
VU University Medical Center
Amsterdam,  Netherlands

Speaker(s):

Matthew  Vander Heiden, MD, PhD
Koch Institute for Cancer Research at Massachusetts Institute of Technology 
Cambridge,  MA,  USA
Cellular Bioenergetics in Lymphoid Neoplasia

Clark  W.  Distelhorst, MD
Case Western Reserve University 
Cleveland,  OH,  USA
Autophagy and Metabolism in Lymphoid Malignancies

Chi  Van  Dang, MD, PhD
University of Pennsylvania 
Philadelphia,  PA,  USA
Therapeutic Targeting of Cancer Cell Metabolism in Lymphoid Neoplasia

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Scientific Committee on Myeloid Biology

Gene Regulatory Networks in Myeloid Reprogramming

Chair(s):

Benjamin  L.  Ebert, MD, PhD
Brigham and Women's Hospital
Boston,  MA,  USA

Speaker(s):

Koichi  Akashi, MD, PhD.
Kyushu University Hospital 
Fukuoka,  Japan
Transcriptional Regulation in Normal and Malignant Hematopoiesis

Berthold  Göttgens, DPhil
University of Cambridge 
Cambridge,  United Kingdom
Genome-Wide Programming of Myeloid Cell Fates

Tariq  Enver, Ph.D., Prof.
University College London 
London,  United Kingdom
Gene Regulatory Networks Governing Hematopoietic Stem Cell Development and Identity

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Scientific Committee on Myeloid Neoplasia

DNA Methylation Pathways in Myeloid Neoplasia

Chair(s):

Michelle  M.  Le Beau, PhD
University of Chicago Comprehensive Cancer Center
Chicago,  IL,  USA

Speaker(s):

Timothy  J.  Ley, MD, on behalf of Genomics of AML Program Project Grant
Washington University School of Medicine 
St. Louis,  MO,  USA
DNMT3A Mutations in Acute Myeloid Leukemia

Anjana  Rao, PhD
La Jolla Institute for Allergy and Immunology 
La Jolla,  CA,  USA
TET2: Mechanism and Functional Consequences of Hydroxymethylation

Ari  M.  Melnick, MD
Weill Cornell Medical College 
New York,  NY,  USA
Epigenetic Effects of IDH1/IDH2 Mutations

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Scientific Committee on Platelets

Platelets in Disease of Inflammation

Chair(s):

Jing-Fei  Dong, MD, PhD
Baylor College of Medicine
Houston,  TX,  USA

Speaker(s):

Jane  Freedman, MD
Boston University School of Medicine 
Boston,  MA,  USA
Platelets, Obesity, and the Metabolic Syndrome

Eric  Boilard, PhD
Laval University 
Quebec,  QC,  Canada
Functions of Platelet Microparticles in Inflammatory Arthritis

Jasimuddin  Ahamed, PhD
The Rockefeller University 
New York,  NY,  USA
Systemic Platelet TGF-β1 Release and Activation: Linking Hemostasis, Inflammation, and Fibrosis

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Scientific Committee on Red Cell Biology

Cell and Molecular Biology of Hypoxia: Hypoxia-Inducible Factors

Chair(s):

Stephen  J.  Brandt, MD
Vanderbilt University Medical Center
Nashville,  TN,  USA

Speaker(s):

M.  Celeste  Simon, PhD
University of Pennsylvania School of Medicine 
Philadelphia,  PA,  USA
Oxygen Availability and Stem Cells: Impact On Development and Disease

Michael  Ohh, PhD
University of Toronto 
Toronto,  ON,  Canada
Negative Regulation of HIF Via VHL Tumor Suppressor Complex

Richard  K.  Bruick, PhD
The University of Texas Southwestern Medical Center at Dallas 
Dallas,  TX,  USA
Modulation of HIF-2 Function with Small Molecules: Did Nature Beat Us to It?

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Scientific Committee on Stem Cells and Regenerative Medicine

Building Better Stem Cells: Strategies to Enhance Regenerative Potential

Chair(s):

Amy  J.  Wagers, PhD
Joslin Diabetes Center, Harvard Medical School
Boston,  MA, 

Speaker(s):

Elizabeth  Blackburn, PhD
University of California, San Francisco 
San Francisco,  CA,  USA
Implication of Telomerase in Functions Besides Telomere Elongation in Human Cells

Emmanuelle  Passegué, PhD
University of California, San Francisco 
San Francisco,  CA,  USA
Strategies for Genome Repair in Normal and Leukemic Stem Cells

Michael  P.  Cooke, PhD
Genomics Institute of the Novartis Research Foundation 
San Diego,  CA,  USA
Small Molecule Screens for Stem Cell Expansion

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Scientific Committee on Thrombosis and Vascular Biology

Proteases and the Vessel Wall

Chair(s):

Wadie  F.  Bahou, MD
State Univ. of New York
Stony Brook,  NY,  USA

Speaker(s):

Athan  Kuliopulos, MD, PhD
Tufts University School of Medicine 
Boston,  MA,  USA
Matrix Metalloproteases and PAR Activation

John  H.  Griffin, PhD
The Scripps Research Institute 
La Jolla,  CA,  USA
Activated Protein C Cellular Pathways Regulating Thrombosis

Patricia  Andrade-Gordon, PhD
Johnson & Johnson Pharmaceutical Research and Development 
Spring House,  PA,  USA
Challenges in Design and Development of PAR Inhibitors

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Scientific Committee on Transfusion Medicine

Genetic Manipulation of Hematopoietic Stem Cells for Transfusion Therapy

Chair(s):

Edward  L.  Snyder, MD
Yale-New Haven Hospital, Yale Medical School
New Haven,  CT,  USA

Speaker(s):

Marina  Cavazzana-Calvo, MD, PhD
Hôpital Necker-Enfants Malades 
Paris,  France
HSC Transplantation for Hemoglobinopathies: Allogeneic or Autologous Gene-Modified HSC?

Eirini  P.  Papapetrou, MD, PhD
Memorial Sloan-Kettering Cancer Center 
New York,  NY,  USA
Genomic Safe Harbors in Human iPS Cells

Valder  R.  Arruda, MD, PhD
University of Pennsylvania School of Medicine 
Philadelphia,  PA,  USA
Hemophilia Gene Therapy

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Scientific Committee on Transplantation Biology

Genomics and Proteomics of Transplantation

Chair(s):

Brenda  M.  Sandmaier, MD
Fred Hutchinson Cancer Research Center and University of Washington
Seattle,  WA,  USA

Speaker(s):

Effie  W.  Petersdorf, MD
Fred Hutchinson Cancer Research Center 
Seattle,  WA,  USA
Genetics of Graft-Versus-Host Disease

Sophie  Paczesny, MD, PhD
University of Michigan 
Ann Arbor,  MI,  USA
Discovery and Validation of Graft-Versus-Host Disease Biomarkers

Marcel  R.M.  van den Brink, MD, PhD
Memorial Sloan-Kettering Cancer Center 
New York,  NY,  USA
Genetics of Intestinal Graft-Versus-Host Disease

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