Case Study: GI Bleed in a Patient with Amyloidosis
A board-style question with an explanation and a link to a relevant article is a recurring feature of TraineE-News. The goal of the case study is to clarify specific and timely teaching points in the field of hematology. The following case study focuses on a 59-year-old male who is seen by his cardiologist for a new restrictive cardiomyopathy. He is found to also have an elevated serum creatinine, and, with concern for amyloidosis, the patient undergoes a fat pad biopsy. Pathologic evaluation displays apple-green birefringence under polarized light when stained with Congo red dye. You see him in clinic shortly thereafter. His physical exam is unremarkable except for a loud S4 on auscultation of the heart and mild hepatomegaly. Further laboratory work-up reveals an elevation of his λ free light chains along with an increased number of plasma cells in the bone marrow. His CBC is below.
|Hemoglobin||10.2 g/dL ||(13.5-17.5 g/dL) |
|WBC||6.8 K/µL||(4.0- 11.0 K/µL)|
|Platelet count ||154 K/µL ||(150-400 K/µL)|
You plan on treating him with bortezomib-based regimen in three days, but he is admitted to the hospital prior with a GI bleed. Labs on admission to the hospital are as follows.
|Hemoglobin ||8.8g/dL ||(13.5-17.5 g/dL) |
|WBC||6.1 K/µL||(4.0-11.0 K/µL)|
|Platelet count ||168 K/µL ||(150- 400 K/µL)|
|Prothrombin time||17 sec. ||(11- 13.5 sec.)|
What is the most likely etiology of the patient's bleeding?
- Factor II deficiency
- Glanzman thrombasthenia
- Acquired von Willebrand factor deficiency
- Factor VIII deficiency
- Factor X deficiency
- Factor X deficiency
In patients with immunoglobulin light-chain (AL)-amyloidosis, bleeding complications have been well described. The most common culprit for abnormal hemostasis that has been reported is factor X deficiency, occurring in 8.7 to 14 percent of patients with AL-amyloidosis. It is thought that the factor X is absorbed by the amyloid fibrils. Other factor deficiencies have been found in patients with AL-amyloidosis, but they are extremely rare. The most common sites of hemorrhage in patients with a factor X deficiency and AL-amyloid are cutaneous followed by the GI tract. In patients who are treated for their amyloidosis and achieve a complete remission, factor X levels almost always return to normal.
- Mumford AD, O’Donnell J, Gillmore JD, et al. Bleeding symptoms and coagulation abnormalities in 337 patients with AL-amyloidosis. Br J Haematol. 2000;110:454-460.
- Choufani EB, Sanchorawala V, Ernst T, et al. Acquired factor X deficiency in patients with amyloid light-chain amyloidosis: incidence, bleeding manifestations, and response to high-dose chemotherapy. Blood. 2001;97:1885-1887.
Case study submitted by Mark A. Walshauser, MD, Loyola University, Maywood, IL, Trainee Council Member.
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