American Society of Hematology

ASH Clinical Practice Guidelines

ASH develops and publishes evidence-based clinical practice guidelines to help members and other practicing hematologists improve diagnosis, treatment, and patient care. Browse the existing guidelines below and learn about guidelines currently in development.

Venous Thromboembolism

A collaboration with the McMaster University GRADE Center, 10 guidelines will be published in 2018 on the diagnosis and treatment of venous thromboembolism.

Sickle Cell Disease

Five new guidelines on the management of acute and chronic complications of sickle cell disease are currently in development, with publication expected in 2019.

Epoetin and Darbepoetin

This ASH-ASCO guideline features the latest research and guidelines about the use of epoetin for the treatment of cancer-related anemia.

Immune Thrombocytopenia

Published in 2011, this guideline is an evidence-based analysis of the diagnosis and management of idiopathic thrombocytopenia.

Initial Workup of Acute Leukemia

Published in partnership with the College of American Pathologists, this guideline addresses the initial work-up of acute leukemia.

Laboratory Workup of Lymphoma

Learn about ASH’s new guideline collaboration with the American Society for Clinical Pathology and the College of American Pathologists.

ASH’s guideline development is overseen by the ASH Guideline Oversight Subcommittee, which selects guideline topics, vets and appoints individuals to serve on guideline panels, and determines policies and procedures for guideline development. This subcommittee reports to the ASH Committee on Quality.

ASH also endorses other clinical guidelines of relevance to practicing hematologists.

Venous Thromboembolism (VTE)

ASH is collaborating with McMaster University to develop 10 clinical practice guidelines on the diagnosis and treatment of venous thromboembolism (VTE).

Publication of the following guidelines is anticipated in 2018:

  • Prevention of VTE in surgical patients
  • Prevention of VTE in nonsurgical patients
  • Diagnosis of VTE
  • Thrombophilia
  • Treatment of VTE (deep vein thrombosis and pulmonary embolism)
  • Optimal management of anticoagulation therapy
  • Heparin-induced thrombocytopenia
  • Prevention and treatment of VTE in patients with cancer
  • VTE in the context of pregnancy
  • VTE in pediatric populations

In 2015, as part of the guideline development process, ASH and the McMaster University GRADE Center formed a coordination panel and 10 expert guideline development panels. The panels are made up of more than 100 individuals, including U.S.-based and international hematologists, clinicians from other specialties, scientists with expertise in evidence synthesis and appraisal and guideline development methodology, and patient representatives.

Listen to the podcasts below to learn more about ASH's VTE guidelines.

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Sickle Cell Disease (SCD)

ASH is developing new clinical practice guidelines on the management of acute and chronic complications of sickle cell disease (SCD). Topics to be addressed include pain, cerebrovascular disease, cardiopulmonary and kidney disease, stem cell transplantation, and transfusion support.

Publication of the five guidelines is anticipated in 2019.

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Initial Workup of Acute Leukemia

"Initial Diagnostic Work-up of Acute Leukemia: Guideline From the College of American Pathologists and the American Society of Hematology"

On February 22, 2017, the College of American Pathologists (CAP) and the American Society of Hematology (ASH) published an evidence-based guideline that addresses the initial work-up of acute leukemia. The guideline was published in an early online edition of the Archives of Pathology and Laboratory Medicine.

The guideline defines the recommended clinical information and laboratory testing needed for proper diagnosis, with the goal of optimal prognosis of pediatric and adult patients with acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and mixed-phenotype acute leukemia (MPAL).

ASH and CAP have provided a mini-review that explains the impetus for the guideline and outlines the recommendations.

The guideline recommendations are also available as a printed pocket guide and in the ASH Pocket Guides app (available on iOS and Android).

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Immune Thrombocytopenia

Clinical Practice Guideline on the Evaluation and Management of ITP

Published in Blood on April 21, 2011, this guideline is an evidence-based analysis of the diagnosis and management of idiopathic thrombocytopenia developed by a panel of specialists sponsored by ASH.

In 2015, ASH convened an expert panel to revise the 2011 guidelines. Systematic evidence review and methodological support for these guidelines is provided by the University of Oklahoma Health Sciences Center. Publication of the revised guidelines is expected in 2018.

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Epoetin and Darbepoetin

"ASH-American Society of Clinical Oncology (ASCO) 2010 clinical practice guideline update on the use of epoetin and darbepoetin"

Published in Blood on November 18, 2010, this guideline features the latest research and evidence-based clinical guidelines about the use of epoetin for the treatment of cancer-related anemia.

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Laboratory Workup of Lymphoma

The American Society for Clinical Pathology (ASCP), the College of American Pathologists (CAP), and the American Society of Hematology (ASH) are collaborating to develop a practice guideline on the laboratory workup of patients with suspected lymphoma.

An expert panel formed in 2017 includes both hematopathologists and clinical hematologists representing the three collaborating organizations. The guideline will address laboratory ordering and communications, specimen handling, and diagnostic and prognostic testing including molecular testing.

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