American Society of Hematology

Apply for the ASH Clinical Research Training Institute

CRTI_Video_ThumbnailClick image to play video with CRTI faculty member Dr. Ruben Mesa

The Clinical Research Training Institute (CRTI) offers trainees the opportunity to:

  • Discuss the principles of clinical research design and execution, including clinical trials with correlative science objectives.
  • Recognize the ethical and regulatory issues of clinical research.
  • Examine the fundamentals of competitive grant writing, abstract presentation, and manuscript preparation.
  • Demonstrate improvements in the quality of their own research proposals through input from faculty and peers.
  • Formulate strategies for pursuing and developing successful careers in hematology research.
  • Discuss approaches to forming and sustaining a multi-disciplinary clinical research team.
  • Practice preparing research results and presenting their work to diverse audiences.
  • Develop contact with other trainees to facilitate future collaborations.
  • Develop relationships with leaders in clinical research who can enhance professional networking opportunities.
  • Formulate strategies for maximizing the benefits and avoiding potential pitfalls in mentor-mentee relationships.

Workshop Curriculum

During the mandatory summer workshop, participants are matched with faculty members and small groups, which provide intensive exposure to mentorship and networking resources. Each day is divided into didactic sessions and small group meetings, with mornings dedicated to lectures on patient-oriented clinical research methodology and related topics. In the afternoons, participants meet with their small groups, workshop mentors, and other faculty, including biostatisticians, to work on protocol development. Informal presentations by leaders in hematology clinical research take place in the evenings.

Throughout the week, participants develop their own proposed patient-oriented clinical research projects, refining and revising their plans through interaction with faculty and peers.

Highlights of the summer workshop curriculum include:

  • Advantages and disadvantages of observational studies and meta-analysis
  • Advice for forming and sustaining a multi-disciplinary clinical research team, including basic science colleagues
  • Tools for assessing the quality of clinical research in the field
  • Advice on using mentoring and networking to your advantage
  • Overview of the design, conduct, analysis, and interpretation of epidemiologic studies of diseases in humans
  • Strategies for securing research funding from the National Institutes of Health (NIH) and foundations that support hematology research
  • Introduction to skills necessary for presenting work to diverse audiences
  • Advice on preparing research results for publication
  • Overview of basic statistical terms, sample size calculation, and interpretation of results in clinical trials
  • Advice on successfully interfacing with industry while maintaining research independence
  • Application of translational laboratory studies to facilitate early phase I/II clinical trials
  • Overview of regulatory rules governing clinical trials
  • Advice on strategies for successful collaborative research in cooperative groups by junior faculty
  • Formal planning of career development and aims for a successful K23 or K08 application or a similar award application
  • Methods and consultation for effective and efficient literature searches
  • Overview of patient-reported outcomes in clinical trials
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Webinars

Watch the following webinars designed to help you prepare for CRTI and enhance your experience in the program.

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Eligibility Requirements

CRTI is geared toward trainees and early-career faculty in hematology-related programs at academic medical centers. Applicants must meet the following criteria to qualify for CRTI:

  • Be an ASH member in good standing. To verify your membership status, please log in to your ASH account. Not an ASH member yet? Take the first step. Your membership application must be pending at the time of CRTI eligibility form submission and approved by the application deadline.
  • Be fluent in English
  • For North American applicants: Be in hematology-related fellowship training, or be a junior faculty member who has completed his/her fellowship training within the past three years.
    • Fellowship training is defined as any sub-specialty training in hematology irrespective of whether this training is concurrent with another training program. The first faculty position is defined as the first position as an instructor (or equivalent) or assistant professor in a hematology-related discipline irrespective of whether the applicant has held a previous faculty position in a field unrelated to hematology.
  • For international applicants: Be a fellow who at the time of application has received his/her MD within the past 12 years, or be a faculty member who at the time of application has completed his/her fellowship training within the past five years.

Please note: Individuals who have concurrent funding through the ASH-EHA Translational Research Training in Hematology program or ASH Scholar Award are not eligible to apply.

Applicants doing research in the same department of an institution are eligible to apply; however, no more than one applicant from any one department at any one institution will be selected. In this context, different departments include internal medicine, pediatrics, pathology, etc. Institutions with multiple potential applicants should consider having an internal selection process to avoid an excessive number of applications.

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Research Project Requirements

CRTI is intended to foster the development of a real project that the participant will move forward throughout the year-long program. All applicants must submit a research proposal as part of the application process. Completion of the proposal within the year of CRTI is not necessary; however, a clear plan for the timeline of the study and data analysis is essential.

  • The project submitted to CRTI cannot be under consideration for or have been presented at any other similar clinical research development workshops.
  • Studies submitted to CRTI must directly involve clinical observation of human subjects.
  • Research projects must include the development or study of new diagnostic methods, therapies, and/or outcome measures that ultimately will benefit patients with hematologic disorders.
  • Studies that will be open to enrollment before September 2017 are not eligible nor are studies which will have obtained Institutional Review Board approval by the date of the CRTI workshop.
  • Studies that are exclusively laboratory based are not appropriate.
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Application Process

The CRTI application, as well as all supporting documents outlined below, must be submitted through the ASH online awards portal. Only those who have fulfilled the eligibility review requirements will be invited to apply.

All applications must include the following:

  • Applicant NIH Biographical Sketch
  • Applicant Career-Development Plan
  • Research Proposal and References
  • Research Mentor NIH Biographical Sketch
  • Research Mentor Letter of Support
  • Institutional Commitment Letter
  • For applicants in their final year of training who plan to transition to another institution: A support letter from the new institution must be provided in addition to one from the current institution. The applicant must also state the feasibility of completing his/her proposed research project at the new institution.
  • For applicants with K-type grants who have access to or involvement in educational programs that cover material included in CRTI: The applicant will need to describe the ways in which CRTI participation would provide him/her with further benefit and training.

For more information about the required materials, please see the Required Documents PDF.

Apply now

All eligibility review and application submissions will be sent a confirmation email. If you do not receive a confirmation email, please contact the ASH Training Coordinator at training@hematology.org or 202-552-4928.

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Evaluation, Selection, and Notification

Each application will be reviewed by a primary, secondary, and tertiary reviewer. Applications will be evaluated on the following criteria:

  • The applicant’s personal qualifications, as assessed by the biosketch, and potential for academic success, as assessed by the career-development plan.
  • The proposal’s originality, feasibility, and clinical importance. Preference will be given to proposals with greater involvement of clinical observations.
  • The mentor’s experience and plans for supporting the applicant, as evidenced by the mentor’s biosketch and letter of support. As mentorship is considered a critical component of a successful CRTI experience, the mentor’s letter of support will be carefully examined and contribute substantially to the applicant’s score.
  • The institutional support, as evidenced by the institutional commitment letter.

Finalists selected to participate in CRTI will be notified in June and will receive a written review and critique of their proposal. If an applicant is accepted and knows that the original proposal is no longer feasible (i.e., lack of drug access, etc.), the individual must resubmit another possible project no later than two weeks before the start of the summer workshop. The co-directors will review the new proposal and determine if the individual is still eligible to attend. If the revised application is not approved, the next applicant on the rank list will be invited to attend.

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Term and Conditions

As a condition of acceptance to the Clinical Research Training Institute, you are required to:

  • Maintain ASH membership throughout the duration of the program (from the time the eligibility review form is due through the final project update meeting).
  • Adhere to all required deadlines.
  • Attend all parts of the three-part program:
    1. The week-long summer workshop held in August in La Jolla, California. (Due to the intense nature of the workshop, participants are not allowed to bring guests, family, or significant others to the workshop.)
    2. Small group meeting and CRTI reception at the ASH annual meeting in December.
    3. All-day final class meeting held in May at ASH Headquarters in Washington, DC. At the final meeting, participants will present progress reports on their projects and personal development as clinical/translational investigators.

Please note: ASH will pay for participants’ travel and hotel expenses to attend the summer workshop and spring meeting; however, travel, hotel, and incidental expenses associated with attending the ASH annual meeting are the responsibility of the participant and/or the participant’s academic institution.

  • Make airline reservations through EWA Travel, ASH’s official travel agent.
  • Attend and participate in each small group meeting during the summer workshop.
  • Give a PowerPoint presentation on your submitted research proposal on the first and last day of the CRTI and at the final class.
  • Have scheduled status updates with your CRTI mentor
  • Complete the ASH Conflict-of-Interest (COI) form and abide by the ASH COI policy.
  • Execute a confidentiality agreement.
  • Cite support from the American Society of Hematology in any publications resulting from the CRTI project.
  • Respond to future inquiries from ASH regarding your career progression.

Acceptance into CRTI cannot be transferred or deferred.

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Questions?

If you have any questions or require additional information regarding the ASH Clinical Research Training Institute, please contact training@hematology.org.
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