American Society of Hematology

Friday Scientific Workshops

The application period for the 2018 workshops is now closed.

The Friday Scientific Workshops are interactive discussions of the latest science developments in a particular field of hematology. All registered ASH annual meeting attendees are welcome to attend these workshops; there is no fee to attend.

Please check back closer to the meeting for detailed information about the 2018 workshops.

For questions about the Friday Scientific Workshops, please contact ASH Scientific Programs Specialist Nneka Iwuchukwu at niwuchukwu@hematology.org.

2017 Friday Scientific Workshops

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Hematology & Aging: Highlighting Novel Science and Promoting a Research Agenda

This workshop will discuss scientific findings related to aging and hematologic disorders, spanning topics from bench to bedside.

Co-Chairs: Rebecca L. Olin, MD, and Tanya M. Wildes, MD, MSCI

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Hemoglobin Concentrations for Defining Anemia in Individuals and Populations

This workshop will present key scientific data underlying the process of evaluating current WHO thresholds for defining anemia.

Chair: Sant-Rayn Pasricha, MD, PhD

Inherited Hematopoietic Malignancies

This workshop will discuss the scientific advances in understanding the pathogenesis of cancer development in individuals and families with germline mutations and predisposition to bone marrow derived malignancies.

Chair: Lucy Godley, MD, PhD

Integrative Clinical & Molecular Epidemiology of Hematologic Malignancies

This workshop will highlight aspects of clinical and molecular epidemiology with emphasis on non-malignant precursor disease states and the factors associated with transformation of hematologic malignancy.

Co-Chairs: Wendy Cozen, DO, and James M. Foran, MD

Myeloid Development

This workshop will examine the latest scientific findings in myeloid biology, with a focus on hematopoietic stem cell biology, leukemogenesis, cell signaling, transcription factors, and epigenetic effects.

Co-Chairs: Leonard Zon, MD, and Ross L. Levine, MD

Tumor Immune Interactions in Lymphoid Malignancies

This workshop will highlight basic and translational immune research as well as potential likely to be important in treating lymphoid malignancies.

Co-Chairs: Stephen M. Ansell, MD, PhD, and Ronald Levy, MD

Friday Scientific Workshop on Hematology and Aging: Highlighting Novel Science and Promoting a Research Agenda

Workshop Schedule

Opening Remarks

Chair:

Rebecca L. Olin, MD
University of California, San Francisco
San Francisco, CA

Co-Chair:

Tanya M. Wildes, MD, MSCI
Washington University School of Medicine
St Louis, MO

Stem Cells and Aging

Moderator:

Ashley E. Rosko, MD
The Ohio State University
Columbus, OH

Speakers:

Michael Gustave Poulos, PhD
Weill Cornell Medical College
New York, NY
Aging Vascular Endothelium Modulate Hematopoietic Stem Cell Activity

Gerald De Haan, PhD
University of Groningen
Groningen, Netherlands
Molecular Mechanisms That Contribute to Hematopoietic Stem Cell Aging

Laura M. Calvi, MD
University of Rochester School of Medicine and Dentistry
Rochester, NY
Defects in Aging Marrow Macrophages Regulate Hematopoietic Stem Cells

Cynthia E. Dunbar, MD
National Institutes of Health
Bethesda, MD
Creation of a Non-Human Primate Model for Hematopoietic Aging and for Chip

Panel Discussion/Questions

Aging, Inflammation and Immune Function

Moderator:

Andrew Artz, MD
University of Chicago
Chicago, IL

Speakers:

Hartmut Geiger, PhD
Cincinnati Children's Hospital Medical Center
Cincinnati, OH
Stem Cells Aging and Immunity

Fabienne Lucas, MD PhD
The Ohio State University Wexner Medical Center
Columbus, OH
Transplant as a Model for Accelerated T-Cell Aging

Bindu Kanapuru, MD
U.S. Food and Drug Administration
Vienna, VA
Immunotherapy in Older Adults with Hematological Malignancies

Vu Luan Dang Chi, MD
Free University of Brussels
Brussels, Belgium
Age-Related BACH2 Expression Down-Regulation and Decreased Apoptosis in Major Lymphocyte Subsets in Healthy Donors and B-Chronic Lymphocytic Leukemia Patients.

Panel Discussion/Questions

Thrombosis and Aging

Moderator:

Matthew T. Rondina, MD
University of Utah
Salt Lake City, UT

Speakers:

Matthew T. Rondina, MD
George E Wahlen VAMC Geriatric Research and Education Clinical Center
Salt Lake City, UT
Platelet Reprogramming and Thrombosis in Aging

Alisa S. Wolberg, PhD
University of North Carolina at Chapel Hill
Chapel Hill, NC
In Vitro and In Vivo Models to Dissect the Pathophysiology of Thrombosis in Aging

Pavel Davizon-Castillo, MD
University of Colorado - Pediatric Hematology/Oncology/BMT
Aurora, CO
The Megakaryocyte-Platelet Axis and Pro-Thrombotic Functional Responses in a Murine Model of Aging

Panel Discussion/Questions

Clinical and Biologic Correlates of Frailty in Hematology

Moderator:

Heidi Klepin, MD
Wake Forest School of Medicine
Winston-Salem, NC

Speakers:

Paul A. Hamlin, MD
Memorial Sloan-Kettering Cancer Center
New York, NY
Geriatric Assessment Among Older Adults with Lymphoma

Raul Cordoba, MD, PhD
Fundación Jimenez Díaz
Madrid, Spain
Brief Comprehensive Geriatric Assessment in Older Patients with Hematological Malignancies: The Gah Scale. a Nation-Wide Dissemination Strategy to Implement the Tool in Spain

Panel Discussion/Questions

Closing Remarks

Co-Chair:

Tanya M. Wildes, MD, MSCI
Washington University School of Medicine
St Louis, MO

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Friday Scientific Workshop on Hemoglobin Concentrations for Defining Anemia in Individuals and Populations

Workshop Schedule

Opening Remarks

Chair:

Sant-Rayn Pasricha, MD, PhD
Weatherall Institute of Molecular Medicine, University of Oxford
Oxford, United Kingdom

Co-Chair:

Dorine W. Swinkels, MD, PhD
Radboud University Medical Centre
Nijmegen, Netherlands

Hemoglobin Thresholds and Population Health

Moderator:

Dorine W. Swinkels, MD, PhD
Radboud University Medical Centre
Nijmegen, Netherlands

Speakers:

Sant-Rayn Pasricha, MD, PhD
Weatherall Institute of Molecular Medicine, University of Oxford
Oxford, United Kingdom
Overview of the World Health Organization Hemoglobin Thresholds Project

Robert T. Means Jr., MD
East Tennessee State University
Johnson City, TN
Current Hemoglobin Cutoffs: How Did We Get Here?

Elizabeta Nemeth, PhD
University of California, Los Angeles
Los Angeles, CA
Effects of Inflammation on Hemoglobin Concentrations - Mechanisms and Clinical Effects

Melissa Fox Young, PhD
Emory University
Atlanta, GA
Evidence for Hemoglobin Thresholds and Functional Outcomes in Young Children and in Pregnancy

Parmi Suchdev, MD, MPH
Emory University
Atlanta, GA
The Epidemiology and Determinants of Anemia in Low Income Countries

Max Gassmann, DVM
University of Zurich
Zurich, Switzerland
Effects of Hypoxia, Altitude and Smoking on Hemoglobin Concentrations

Hemoglobin Thresholds and Clinical Medicine

Moderator:

Sant-Rayn Pasricha, MD, PhD
Weatherall Institute of Molecular Medicine, University of Oxford
Oxford, United Kingdom

Speakers:

Domenico Girelli, MD, PhD
University of Verona
Verona, Italy
Hemoglobin Thresholds in the Elderly

Erica Wood, MD
Monash University
Melbourne, Australia
Hemoglobin Concentrations and Transfusion Thresholds

Dorine W. Swinkels, MD, PhD
Radboud University Medical Centre
Nijmegen, Netherlands
Laboratory Measurement of Hemoglobin in Clinical Laboratory Practice and the Field

Stefano Rivella, PhD
Children’s Hospital of Philadelphia
Philadelphia, PA
Erythroid Genetics and Hemoglobin Concentrations

Conclusions and Study Needs

Panelists:

Maria Nieves Garcia-Casal
World Health Organization
Genève, Switzerland

Andrea Sharma, PhD, MPH
Centers for Disease Control and Prevention
Atlanta, GA

Closing Remarks

Chair:

Sant-Rayn Pasricha, MD, PhD
Weatherall Institute of Molecular Medicine, University of Oxford
Oxford, United Kingdom

Co-Chair:

Dorine W. Swinkels, MD, PhD
Radboud University Medical Centre
Nijmegen, Netherlands

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Friday Scientific Workshop on Inherited Hematopoietic Malignancies

Workshop Schedule

Opening Remarks

Chair:

Lucy Godley, MD,PhD
University of Chicago
Chicago, IL

Identification of Germline Syndromes

Moderators:

Jun J. Yang, PhD
St. Jude Children's Res. Hosp.
Memphis, TN

Alison A. Bertuch, MD, PhD
Texas Children's Hospital
Houston, TX

Speakers:

Blanche P. Alter, MD, MPH
National Institutes of Health National Cancer Institute
Rockville, MD
MDS in Inherited Bone Marrow Failure Syndromes

Christian P. Kratz, MD
Hannover Medical School
Hannover, Germany
Children with Cancer Predisposition Syndromes in Germany: Activities of the Society of Pediatric Oncology and Hematology

Christopher N. Hahn, PhD
SA Pathology
Adelaide, SA, Australia
Surprises in "Solving" Families with Predisposition to Hematopoietic Malignancy

Courtney D. DiNardo, MD,MSc
UT MD Anderson Cancer Center
Houston, TX
Incorporating MDS/AML Molecular Profiling at Diagnosis into the Evaluation of Hereditary Leukemia Predispositions

Sarah Bannon, MS, CGC
The University of Texas MD Anderson Cancer Center
Houston, TX
Unique Role of Genetic Counselors in Hematologic Malignancies

Novel Aspects of Known Predisposition Syndrome

Moderators:

Hamish S. Scott, PhD, FFSc (RCPA), FAHMS
SA Pathology & University of South Australia
Adelaide, Australia

Marcin W. Wlodarski, MD, PhD
University of Freiburg
Freiburg, Germany

Speakers:

Emilia J. Kozyra, MSc
University Childrens Hospital Freiburg
Freiburg, Germany
Synonymous Exonic Substitutions Constitute a New Class of Mutations Causing GATA2 Deficiency

Hideki Makishima, MD, PhD
Kyoto University
Kyoto, Japan
Comprehensive Evaluation of DDX41 Risk Alleles in Non-Familial Cases, General Individuals, and Donor-Derived Leukemias

Jorge Di Paola, MD
University of Colorado School of Medicine
Englewood, CO
A Novel Murine Model of an ETV6 Germline Mutation

Bianca Tesi, MD
Karolinska Institute
Stockholm, Sweden
Clinical and Molecular Features of Patients with SAMD9L-Germline Mutations

Gary M. Kupfer, MD
Yale School of Medicine
New Haven, CT
Fanconi/BRCA Recombination Activity in Vitro and in Cells and Enhancement of Cancer Therapy

Emerging New Syndromes

Moderators:

Mary Y. Armanios, MD
Johns Hopkins University
Baltimore, MD

Prapti A. Patel, MD
University of Texas Southwestern
Dallas, TX

Speakers:

Victor Pastor Loyola, MSc
Freiburg University Hospital
Freiburg, Germany
Familial MDS and Transient Monosomy 7 as a Sole Clinical Manifestation of SAMD9L-disease

Ian Majewski, PhD
The Walter and Eliza Hall Institute of Medical Research
Parkville, Victoria, Australia
A New Cancer Predisposition Syndrome with a Common Path to AML

ANA Rio-Machin, PhD, BS
Queen Mary University of London
London, United Kingdom
Challenge of Identifying Novel Predisposing Variants in Familial MDS/AML

Tim Ripperger, MD, PhD
Hannover Medical School
Hannover, Germany
Mecom/EVI1: A Novel Candidate Gene for Hereditary Hematological Malignancies

Effects of Combinations of Germline Variants Including Penetrance/Molecular Progression

Moderators:

Elizabeth A. Griffiths, MD
Roswell Park Cancer Institute
Buffalo, NY

Carolyn Jane Owen, MD, FRCPC
Foothills Hospital & Tom Baker Cancer Center
Calgary, AB, Canada

Speakers:

Inga Hofmann, MD
University of Wisconsin
Madison, WI
Predisposition to Pediatric Myelofibrosis and Thrombocytopenia

Csaba Bödör, PhD
Semmelweis University
Budapest, Hungary
JAK/STAT Pathway Aberrations in RUNX1 Mutated Patients

Thomas Laframboise, PhD
Case Western Reserve University
Cleveland, OH
Germline Contributors to Myeloid Malignancy Susceptibility: Integrating Clues from the Malignant Genome

Kim E. Nichols, MD
St. Jude Children's Research Hospital
Memphis, TN
Hiding Beneath the Surface: Unbiased Screening of the Germline Identifies Unsuspected Cancer Predispositions in Pediatric Leukemia Patients

Reporting of Families and Variant Interpretation

Moderators:

Marshall Horwitz, MD
University of Washington
Seattle, WA

Michael Francis Walsh, MD
Memorial Sloan-Kettering Cancer Center
New York, NY

Speakers:

Matthew P. Collin, MD, PhD
Newcastle University
Newcastle Upon Tyne, United Kingdom
Immune Defects Associated with GATA2 Mutation

Karin Wadt, MD, PhD
Rigshospitalet Copenhagen
Copenhagen, Denmark
Reporting in Scandanavian Populations

Isabelle Plo, PhD
Gustave Roussy
Villejuif, France
Predisposition to Familial MPNs

Jeffery M. Klco, MD, PhD
St. Jude Children's Research Hospital
Memphis, TN
SAMD9/9L Germline Mutations in Familial MDS/AML

Point-Counter Point: Prophylactic Transplantation for Leukemia Predisposition Syndromes

Moderators:

Christopher C. Porter, MD
Emory University
Atlanta, GA

Luke Maese, DO
University of Utah/Primary Children's Hospital
Salt Lake City, UT

Panelists:

Kayla Hamilton, MS, CGC
St. Jude Children's Research Hospital
Memphis, TN

Luke Maese, DO
Priman Children's Medical Center
Salt Lake City, UT

Michael A. Pulsipher, MD
Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine
Los Angeles, CA

Jonathan M Marron, MD,MPH
Children's Hospital Boston, Dana-Farber Cancer Institute
Boston, MA

Closing Remarks

Chair:

Lucy Godley, MD,PhD
University of Chicago
Chicago, IL

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Friday Scientific Workshop on Integrative Clinical & Molecular Epidemiology of Hematologic Malignancies

Workshop Schedule

Opening Remarks

Chair:

Wendy Cozen, DO,MPH
Univ. of Southern California Norris Cancer Ctr.
Los Angeles, CA

Co-Chair:

James M. Foran, MD
Mayo Clinic Florida
Jacksonville, FL

New Findings From Population Studies of B-Cell Lymphoma and Leukemia

Moderators:

James R. Cerhan, MD, PhD
Mayo Clinic
Rochester, MN

Wendy Cozen, DO,MPH
Univ. of Southern California Norris Cancer Ctr.
Los Angeles, CA

Speakers:

Jeffrey M. Switchenko, PhD, MS
Emory University
Atlanta, GA
Geospatial Exposure to Benzene and Lymphoma Risk in Georgia

Susan L. Slager, PhD
Mayo Clinic
Rochester, MN
Genetic Risk Factors for CLL Precursors in Families

Marta Epeldegui, PhD
University of California at Los Angeles, David Geffen School of Medicine
Los Angeles, CA
A Prospective Study of Serum Microbial Translocation and Inflammation Associated Biomarkers and Risk of AIDS-Related Non-Hodgkin Lymphoma

Wendy Cozen, DO,MPH
Univ. of Southern California Norris Cancer Ctr.
Los Angeles, CA
Immunological Aging in Adolescent/Young Adult Hodgkin Lymphoma Survivors Compared to Their Unaffected Twins

Maria S. Oliveira
Instituto Nacional de Câncer
Rio de Janeiro, Brazil
Early-Age Leukemias in Brazil

Smita Bhatia, MD, MPH
University of Alabama at Birmingham
Birmingham, AL
Adherence to Oral Chemotherapy in Children with ALL: Contribution to Disparities in Outcomes

Next Steps for B-cell Neoplasms Epidemiology: Towards Translation

Panelists:

Wendy Cozen, DO,MPH
Univ. of Southern California Norris Cancer Ctr.
Los Angeles, CA

James R. Cerhan, MD, PhD
Mayo Clinic
Rochester, MN

Jeffrey M. Switchenko, PhD, MS
Emory University
Atlanta, GA

Smita Bhatia, MD, MPH
University of Alabama at Birmingham
Birmingham, AL

Marta Epeldegui, PhD
University of California at Los Angeles, David Geffen School of Medicine
Los Angeles, CA

Susan L. Slager, PhD
Mayo Clinic
Rochester, MN

Maria S. Oliveira
Instituto Nacional de Câncer
Rio de Janeiro, Brazil

Epidemiology of Myeloid Malignancy: Precursor States and Risk Factor Update

Moderators:

James M. Foran, MD
Mayo Clinic Florida
Jacksonville, FL

Lindsay M. Morton, PhD
National Cancer Institute, National Institutes of Health
Bethesda, MD

Speakers:

Nancy K. Gillis, PharmD
Moffitt Cancer Center
Tampa, FL
Pre-Existing Chip and Risk of Therapy-Related Myeloid Neoplasms

Koichi Takahashi, MD
The University of Texas M.D. Anderson Cancer Center
Houston, TX
Next Steps with Chip and Myeloid Neoplasms – Informing Risk & Prevention

Sudipto Mukherjee, MD, PhD, MPH
Cleveland Clinic
Cleveland, OH
Risk Prediction for MDS: Novel Clinical and Molecular Risk Factors and Development of Prevention Strategies

Lene Sofie Granfeldt Oestgaard, MD,PhD
Aarhus University Hospital
DK-8000 Aarhus C, Denmark
Clinical Epidemiology & Impact of Therapy-Related AML

Next Steps for Myeloid Neoplasm Clinical & Molecular Epidemiology: Towards Translation

Panelists:

Lindsay M. Morton, PhD
National Cancer Institute, NIH, DHHS
Bethesda, MD

James M. Foran, MD
Mayo Clinic Florida
Jacksonville, FL

Understanding the Risk Pathway of Monoclonal Gammopathy of Undetermined Significance (MGUS) to Myeloma: Contributions From Epidemiology

Moderators:

Wendy Cozen, DO,MPH
Univ. of Southern California Norris Cancer Ctr.
Los Angeles, CA

Ola Landgren, MD, PhD
Memorial Sloan-Kettering Cancer Center
New York, NY

Speakers:

Catherine R. Marinac, PhD
Dana-Farber Cancer Institute
Boston, MA
Elucidating the Association of Obesity with Multiple Myeloma Risk: Prospective Studies of Body Size throughout Life and Weight Stability

Sigurður Yngvi Kristinsson, MD, PhD
University of Iceland
Reykjavik, Iceland
iStopMM - A Nationwide Screening Study of MGUS

Niels Weinhold, PhD
University of Arkansas For Medical Sciences
Little Rock, AR
Functional Follow-up of Potential Risk Variants

Elizabeth E Brown, PhD, MPH
University of Alabama at Birmingham
Birmingham, AL
Differential DNA Methylation Consistent with Progression of Multiple Myeloma

Mark A. Fiala, MSW
Washington University School of Medicine
Saint Louis, MO
Inequalities in Treatment and Outcomes in Multiple Myeloma

Kenneth R. Carson, MD, PhD
Washington University in St. Louis
Saint Louis, MO
Can We Move Towards Prevention in Multiple Myeloma?

T-and NK-cell Lymphoma/Leukemia: Challenges and Opportunities for Epidemiologic Research

Moderators:

Amanda Termuhlen
Children’s Hospital Los Angeles
Los Angeles, CA

Sophia S. Wang, PhD
City of Hope
Duarte, CA

Speakers:

Amanda Termuhlen
Children’s Hospital Los Angeles
Los Angeles, CA
Review of Epidemiology and Risk Factors for Pediatric T-Cell Lymphoma/Leukemia

Sophia S. Wang, PhD
City of Hope
Duarte, CA
Review of Epidemiology of Risk Factors for Adult Peripheral T-Cell Lymphoma/Leukemia

Fredrik Ellin, MD, MSc
Lund University
Lund, Sweden
T-Cell Lymphomas on a Nation-Wide Level - Experiences from the Population-Based Swedish Lymphoma Registry

How to Build an Epidemiological Research Community in T-cell Lymphoma/Leukemia

Panelists:

Sophia S. Wang, PhD
City of Hope
Duarte, CA

Amanda Termuhlen
Children’s Hospital Los Angeles
Los Angeles, CA

Fredrik Ellin, MD, MSc
Kalmar County Hospital
Kalmar, Sweden

Closing Remarks

Chair:

Wendy Cozen, DO,MPH
Univ. of Southern California Norris Cancer Ctr.
Los Angeles, CA

Co-Chair:

James M. Foran, MD
Mayo Clinic Florida
Jacksonville, FL

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Friday Scientific Workshop on Myeloid Development

Workshop Schedule

Opening Remarks

Chair:

Leonard Zon, MD
Harvard University
Boston, MA

Co-Chair:

Ross L. Levine, MD
Memorial Sloan-Kettering Cancer Center
New York, NY

Stem Cells

Moderator:

Patricia Ernst, PhD
University of Colorado Denver Anschutz Medical Campus
Aurora, CO

Speakers:

Marie-Dominique Filippi, PhD, PhD
Cincinnati Children's Hospital Medical Center
Cincinnati, OH
Mitochondrial Morphology Controls Hematopoietic Stem Cell Self-Renewal and Confers Them Divisional Memory

Kira Gritsman, MD, PhD
Albert Einstein College of Medicine
Bronx, NY
The PI3 Kinases Alpha and Delta Are Required for the Loss of Hematopoietic Stem Cell Quiescence during Stress

Wei Tong, PhD
Children's Hospital of Philadelphia
Philadelphia, PA
Lnk/Sh2b3 Deficiency Restores Hematopoietic Stem Cell Function and Genome Integrity in Fanconi Anemia

Grant A. Challen, PhD
Washington University School of Medicine
St Louis, MO
Kdm6b Is Required for Hematopoietic Stem Cell Self-Renewal Under Proliferative Stress

Signaling and Developmental Hematopoiesis

Moderators:

David Traver, PhD
University of California, San Diego
La Jolla, CA

Claudia Lengerke, MD
University Hospital Basel
Basel, Switzerland

Speakers:

Britta Will, PhD
Albert Einstein College of Medicine
Bronx, NY
The Labile Iron Pool As a Rheostat for Hematopoietic Stem Cell Function

Andreas Trumpp, Prof, PhD
Deutsches Krebsforschungszentrum (DKFZ)
Heidelberg, Germany
BCAT1 Restricts a-Ketoglutarate Levels in AML Stem Cells Leading to DNA Hypermethylation Mimicking Idhmut-AML

Jian Xu, PhD
The University of Texas Southwestern Medical Center
Dallas, TX
Interplay between Epigenetics and Metabolism in Hematopoiesis and Leukemia

Toshio Kitamura, MD, PhD
The Institute of Medical Science, The University of Tokyo
Tokyo, Japan
Characterization of Hematopoietic Stem Cells and Progenitors Using a Novel Mouse Expressing a G0 Marker

New Investigators

Moderator:

Nancy E. Speck, PhD
University of Pennsylvania
Philadelphia, PA

Speakers:

Siddhartha Jaiswal, MD, PhD
Brigham and Women's Hospital
Palo Alto, CA
Clonal Hematopoiesis in Human Aging and Disease

Robert S. Welner, PhD
University of Alabama at Birmingham
Birmingham, AL
Transcriptional Hierarchy within the Bone Marrow Niche

Rebekka K. Schneider, MD,PhD
Erasmus University Medical Center
Rotterdam, Netherlands
Megakaryocyte-Mediated Activation of the Transcription Factor Gli1 in Fibrosis-Driving Cells in Myelofibrosis

Vijay G. Sankaran, MD
Boston Children's Hospital
Boston, MA
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis

NHLBI Presentation

Moderator:

John W. Thomas, PhD
National Heart, Lung, and Blood Institute; National Institutes of Health Division of Blood Diseases & Resources
Bethesda, MD

NIDDK Presentation

Moderator:

Terry Rogers Bishop, PhD
National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health
Bethesda, MD

Transcription Factors/Epigenetics

Moderator:

Ulrich G. Steidl, MD, PhD
Albert Einstein College of Medicine
Bronx, NY

Speakers:

Omar Abdel-Wahab, MD
Memorial Sloan-Kettering Cancer Center
New York, NY
Identifying Novel Therapeutic Vulnerabilities in Spliceosomal Mutant Leukemias

Megan E. McNerney, MD, PhD
University of Chicago
Chicago, IL
The 7q Tumor Suppressor, CUX1, Inhibits MDS/MPN in Mice

Lucio H. Castilla, PhD
University of Massachusetts Medical School
Worcester, MA
Role of Cbfbsmmhc / RUNX1 in Maintaining MYC Levels By Modulating Chromatin Dynamics in AML

Shai Izraeli, MD
Tel Aviv University
Modiin, Israel
T/Myeloid Biphenotypic Leukemia Caused By the Fusion Translocation ETV6-NCOA2 (TEL-TIF2)

Myeloid Malignancies

Moderator:

Benjamin L. Ebert, MD, PhD
Dana-Farber Cancer Institute, Harvard Medical School
Boston, MA

Speakers:

Chris Vakoc, MD, PhD
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Domain-Focused CRISPR Dropout Screens in AML

Yana Pikman, MD
Dana Farber Cancer Institute
Boston, MA
New Therapeutic Targets in AML

Jun Lu, PhD
Yale School of Medicine
New Haven, CT
A Non-Cell-Intrinsic Tumor-Promoting Function of Tet2 in Myeloid Cells

Takahiro Maeda, MD,PhD
Kyushu University Hospital
Fukuoka, Japan
Genome-Wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway

Closing Remarks

Chair:

Leonard Zon, MD
Harvard University
Boston, MA

Co-Chair:

Ross L. Levine, MD
Memorial Sloan-Kettering Cancer Center
New York, NY

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Friday Scientific Workshop on Tumor Immune Interactions in Lymphoid Malignancies

Workshop Schedule

Opening Remarks

Chair:

Stephen M. Ansell, MD, PhD
Mayo Clinic
Rochester, MN

Co-Chair:

Ronald Levy, MD
Stanford University School of Medicine
Stanford, CA

New Immune Monitoring Methods

Moderators:

Stephen M. Ansell, MD, PhD
Mayo Clinic
Rochester, MN

Ronald Levy, MD
Stanford University School of Medicine
Stanford, CA

Speakers:

Hanlee Ji, MD
Stanford University
Stanford, CA
Methods and Results from Single Cell Analysis of Tumor Microenvironment

Michael Angelo, MD, PhD
Stanford University
Stanford, CA
In Situ Methods of Analysis of Tumor Microenvironment

Panel Discussion

Novel Targets and Delivery Systems

Moderators:

Stephen M. Ansell, MD, PhD
Mayo Clinic
Rochester, MN

Ronald Levy, MD
Stanford University School of Medicine
Stanford, CA

Speakers:

Paul Sondel, MD, PhD
University of Wisconsin
Madison, WI
New Methods of Tumor Vaccination

June Helen Myklebust, PhD
Oslo University Hospital
Oslo, Norway
Tigit, a New Target in the Tumor Microenvironment

Panel Discussion

Bispecific Antibodies and CAR T cells

Moderators:

Stephen M. Ansell, MD, PhD
Mayo Clinic
Rochester, MN

Ronald Levy, MD
Stanford University School of Medicine
Stanford, CA

Speakers:

Rajat Bannerji, MD, PhD
Cancer Institute of New Jersey
New Brunswick, NJ
Bispecifics Targeting CD20

Renier J. Brentjens, MD, PhD
Memorial Sloan Kettering Cancer Center
Short Hills, NJ
CAR-T Cells: Beyond CD19 (BCMA/CD30/armored CARs)

Panel Discussion

Closing Remarks

Chair:

Stephen M. Ansell, MD, PhD
Mayo Clinic
Rochester, MN

Co-Chair:

Ronald Levy, MD
Stanford University School of Medicine
Stanford, CA

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